Hyaluronic acid hydrogels reinforced with laser spun bioactive glass micro- and nanofibres doped with lithium

last updated: 2021-04-26
TitleHyaluronic acid hydrogels reinforced with laser spun bioactive glass micro- and nanofibres doped with lithium
Publication TypePapers in Scientific Journals
Year of Publication2021
AuthorsAntonio R., Amorim S., Solanki A., Soares da Costa D., Pires R. A., Quintero F., del Val J., Comesaña R., Badaoui A., Lusquinos F., Maçon A. L. B., Tallia F., Reis R. L., and Pou J.
Abstract

The repair of articular cartilage lesions in weight-bearing joints remains as a significant challenge due to the low regenerative capacity of this tissue. Hydrogels are candidates to repair lesions as they have similar properties to cartilage extracellular matrix but they are unable to meet the mechanical and biological requirements for a successful outcome. Here, we reinforce hyaluronic acid (HA) hydrogels with 13-93-lithium bioactive glass micro- and nanofibres produced by laser spinning. The glass fibres are a reinforcement filler and a platform for the delivery of therapeutic lithium-ions. The elastic modulus of the composites is more than three times higher than in HA hydrogels. Modelling of the reinforcement corroborates the experimental results. ATDC5 chondrogenic cells seeded on the composites are viable and more proliferation occurs on the hydrogels containing fibres than in HA hydrogels alone. Furthermore, the chondrogenic behavior on HA constructs with fibres containing lithium is more marked than in hydrogels with no-lithium fibres.

JournalMaterials Science and Engineering C
Volume126
Pagination112-124
Date Published2021-04-23
PublisherElsevier
ISSN09284931
DOI10.1016/j.msec.2021.112124
URLhttps://www.sciencedirect.com/science/article/pii/S0928493121002630
Keywordschondrogenesis, fibres, Hyaluronic acid
RightsopenAccess
Peer reviewedyes
Statuspublished

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