Highly tailorable gellan gum nanoparticles as a platform for the development of T cell activator systems

last updated: 2024-02-06
ProjectCapBed :: publications list
TitleHighly tailorable gellan gum nanoparticles as a platform for the development of T cell activator systems
Publication TypePapers in Scientific Journals
Year of Publication2022
AuthorsRodrigues D. B., Moreira H. R., Cerqueira M. T., Marques A. P., Castro A. G., Reis R. L., and Pirraco R. P.

T cell priming has been shown to be a powerful immunotherapeutic approach for cancer treatment in terms of efficacy and relatively weak side effects. Systems that optimize the stimulation of T cells to improve therapeutic efficacy are therefore in constant demand. A way to achieve this is through artificial antigen presenting cells that are complexes between vehicles and key molecules that target relevant T cell subpopulations, eliciting antigen-specific T cell priming. In such T cell activator systems, the vehicles chosen to deliver and present the key molecules to the targeted cell populations are of extreme importance.

In this work, a new platform for the creation of T cell activator systems based on highly tailorable nanoparticles made from the natural polymer gellan gum was developed and validated. Here, it is demonstrated that the developed system presented a more sustained T cell activation over time when compared to commercial alternatives. Concurrently, the expression of higher levels of key cytotoxic pathway molecules granzyme B/perforin was induced, suggesting a greater cytotoxic potential for future application in adoptive cancer therapy.

JournalBiomaterials Research
Date Published2022-09-30
PublisherBioMed Central
KeywordsCytotoxic T cells, Gellan Gum, Nanoparticles, T cell stimulation
Peer reviewedyes

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