Extracellular Matrix Mimics Using Hyaluronan-Based Biomaterials

last updated: 2021-01-15
ProjectFoReCaST :: publications list
TitleExtracellular Matrix Mimics Using Hyaluronan-Based Biomaterials
Publication TypeReview Paper
Year of Publication2021
AuthorsAmorim S., Reis C. A., Reis R. L., and Pires R. A.
Abstract Text

Hyaluronan (HA) is a critical element of the extracellular matrix (ECM). The regulated synthesis and degradation of HA modulates the ECM chemical and physical properties that, in turn, influence cellular behavior. HA triggers signaling pathways associated with the adhesion, proliferation, migration, and differentiation of cells, mediated by its interaction with specific cellular receptors or by tuning the mechanical properties of the ECM. This review summarizes the recent advances on strategies used to mimic the HA present in the ECM to study healthy or pathological cellular behavior. This includes the development of HA-based 2D and 3D in vitro tissue models for the seeding and encapsulation of cells, respectively, and HA particles as carriers for the targeted delivery of therapeutic agents.

JournalTrends in Biotechnology
Date Published2021-01-02
PublisherCell Press
Keywords3D hydrogels, ECM models, Hyaluronan, particles, Surfaces
Peer reviewedyes

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