Evaluation of novel dendrimer–gold complex nanoparticles for theranostic application in oncology

Aim: Despite some successful examples of therapeutic nanoparticles reaching clinical stages, there is still a
significant need for novel formulations in order to improve the selectivity and efficacy of cancer treatment.
Methods: The authors developed two novel dendrimer–gold (Au) complex-based nanoparticles using two
different synthesis routes: complexation method (formulation A) and precipitation method (formulation
B). Using a biomimetic cancer-on-a-chip model, the authors evaluated the possible cytotoxicity and
internalization by colorectal cancer cells of dendrimer–Au complex-based nanoparticles. Results: The
results showed promising capabilities of these nanoparticles for selectively targeting cancer cells and
delivering drugs, particularly for the formulation A nanoparticles. Conclusion: This work highlights the
potential of dendrimer–Au complex-based nanoparticles as a new strategy to improve the targeting of
anticancer drugs.