Evaluation of Canine Adipose-derived Stem Cells in a Healthy Mice Subcutaneous Model

last updated: 2017-01-11
ProjectRECOGNIZE :: publications list
TitleEvaluation of Canine Adipose-derived Stem Cells in a Healthy Mice Subcutaneous Model
Publication TypePapers in Scientific Journals
Year of Publication2016
AuthorsRequicha J. F., Carvalho P. P., Pires M. A., Dias M. I., Reis R. L., Gomes M. E., and Viegas C. A. A.

Canine adipose-derived stem cells (cASCs) have great interest for cell-based therapies in Veterinary Medicine.
As the behaviour of these cells in non-autologous recipients is not deeply characterized, it is mandatory to study them in new animal models previously to canine specie. In this work, cASCs were injected subcutaneously in mice and these cells were detected by immunohistochemistry using vimentin, CD44 and keratin. The local response evaluated by histology did not reveal signals of significant inflammatory reaction neither in the lymph nodes or other organs.
This study showed the implantation of cASCs induced a scarce inflammatory response. Hsd:CD1 (ICR) mouse can be proposed as an animal model to study the in vivo behavior of the cASCs and to validate new cASCs-based approaches avoiding or reducing the use of dogs in research.

JournalJournal of Stem Cell Research & Therapy
Date Published2016-12-01
Keywordscanine adipose-derived stem cells, Mice Subcutaneous Model
Peer reviewedyes

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