Engineering nanoparticles for targeting rheumatoidarthritis: Past, present, and future trends

last updated: 2018-10-30
ProjectArticulate :: publications list
TitleEngineering nanoparticles for targeting rheumatoidarthritis: Past, present, and future trends
Publication TypeReview Paper
Year of Publication2018
AuthorsOliveira I. M., Gonçalves C., Reis R. L., and Oliveira J. M.
Abstract Text

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial joint inflammation and cartilage and bone tissue destruction. Although there exist some treatment strategies for RA, they are not completely safe and effective. Therefore, it is important to develop and test new drugs for RA that specifically target inflamed/swollen joints and simultaneously attenuate other possible damages to healthy tissues. Nanotechnology can be a good alternative to consider when envisioning precise medication for treating RA. Through the use of nanoparticles, it is possible to increase bioavailability and bioactivity of therapeutics and enable selective targeting to damaged joints. Herein, recent studies using nanoparticles for the treatment of RA, namely with liposomes, polymeric nanoparticles, dendrimers, and metallic nanoparticles, have been reviewed. These therapeutic strategies have shown great promise in improving the treatment over that by traditional drugs. The results of these studies confirm that feasibility of the use of nanoparticles is mainly due to their biocompatibility, low toxicity, controlled release, and selective drug delivery to inflamed tissues in animal RA models. Therefore, it is possible to claim that nanotechnology will, in the near future, play a crucial role in advanced treatments and patient-specific therapies for human diseases such as RA.

JournalNano Research
Date Published2018-04-26
PublisherTsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018
KeywordsDendrimers, Liposomes, Nanoparticles, rheumatoid arthritis
Peer reviewedno

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