Title | Engineering a microvascular 3D microenvironment of colorectal tumour-on-a-chip |
Publication Type | Comunication - Oral |
Year of Publication | 2017 |
Authors | Carvalho M. R., Barata D., Teixeira L. M., Giselbrecht S., Reis R. L., Oliveira J. M., Truckenmüller R., and Habibovic P. |
Abstract | Colorectal cancer is the third most common cancer and its incidence increases with ageing. Understanding the mechanisms of tumour growth rely in further advances to unveil cancer-causing agents, drug screening and in the development of personalized therapies. Standard 2D in vitro models and in vivo animal models have undoubtedly contributed to the development, screening and validation of anti-cancer drug candidates. Nevertheless, recent studies suggest that the correspondence between these models and successful clinical trials is critically low, which reinforces the need of a deeper understanding of tomurogenesis.1 Therefore, 3D models integrating tissue engineering (TE) strategies with microfluidic technology have sparked the expectation on physiologically relevant microfluidic in vitro models. These state-of-the-art dynamic models innovatively adapt to morphological changes in tissue structure and function over time, providing a level of precision control that could not be achieved before.2 |
Conference Name | NBTE 2017 |
Date Published | 2017-11-17 |
Conference Location | Lunteren |
URL | http://nbte.nl/annual-meeting/ |
Keywords | Colorectal, Microfluidics, Microvasculature |
Rights | closedAccess |
Peer reviewed | no |
Status | published |