Elastomeric poly (glycerol sebacate)-based dressing for skin wound healing

last updated: 2019-03-29
ProjectDressing4scars :: publications list
TitleElastomeric poly (glycerol sebacate)-based dressing for skin wound healing
Publication TypeComunications - Poster
Year of Publication2018
AuthorsFernandes M. G., da Silva L. P., Aroso I. M., Reis R. L., and Marques A. P.

Elastomers are important materials for a wide range of biomedical applications including soft tissue engineering. These materials offer stability and structural integrity in dynamic mechanical environments, which cannot be achieved by others biomaterials. Due to this specific features, elastomers such as poly (glycerol sebacate) (PGS) has gained increasing interest. Many studies have reported the use of PGS as a scaffolding material. However, its use as a wound dressing has not yet been properly exploited. Currently, it is known that wound healing requires a suitable and controlled biomechanical environment to promote the healing process. The development of a novel force-modulating dressing capable to control the wound mechanical environment could improve the healing and reduce scarring. Thus, the use of an elastomer with shape memory such as PGS could be a promising wound dressing.

The present study aims to analyse the potential of PGS to develop a suitable dressing for skin wound healing. PGS was prepared from glycerol and sebacic acid via polycondensation and considering different molar ratios (1:1 3:4 4:3). Physical, chemical and mechanical properties were studied by gel permeation chromatography (GPC), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), Proton-Nuclear Magnetic Resonance (1H-NMR) and rheological tests. PGS synthesis was confirmed by 1H-NMR with peaks at δ 1.2, 1.5, 2.2, 3.7, 4.2 and 5.2 ppm. This was also confirmed by FTIR with absorption bands at 2930 cm-1 and 2850 cm-1 corresponding to the alkene groups. PGS prepolymers were synthesised up to a molecular weight of 100 KDa. DSC analysis showed a crystallization point from -7 ⁰C to -17 ⁰C varying with the PGS molar ratios; the melting point was observed at 30 ºC for PGS (1:1) and 32 ⁰C for PGS (3:4) although this temperature transition behavior was not detected for PGS (4:3) in the range of temperature studied (-20 ⁰C to 100 ⁰C). Rheology measurements demonstrated a shear thinning behaviour characterized by the decrease in viscosity with increasing shear rate. The obtained results show that by modifying the ratio of glycerol and sebacic acid, the properties of PGS can be tailored and adjusted to develop a suitable dressing for wound healing.

Conference Name GENE2SKIN Summer School - Biomaterials and molecular mechanisms in the context of skin regeneration
Date Published2018-06-06
Conference LocationPorto, Portugal
Keywordselastomer, poly (glycerol sebacate), wound dressing
Peer reviewedno

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