Project | BREAST-IT: Boosting Research Against Solid Tumor-Immunocompetence Tackling :: publications list |
Title | Biomimetic Antibacterial Pro-Osteogenic Cu-Sericin MOFs for Osteomyelitis Treatment |
Publication Type | Papers in Scientific Journals |
Year of Publication | 2022 |
Authors | Kundu B., Reis R. L., and Kundu S. C. |
Abstract | Osteomyelitis is an inflammation of the bone caused by bacterial infection. It usually develops from broken bones, decayed teeth, or heavily punctured wounds. Multi-drug-resistant bacteria are the major hurdle in the treatment of osteomyelitis. The ever-rising antibiotic resistance even leads to amputations or fatalities as a consequence of chronic osteomyelitis. Hence, a single agent with antibacterial activity as well as bone regenerative properties can serve as a potential off-the-shelf product in the treatment of osteomyelitis. Herein, the antibacterial and pro-osteogenic characteristics of copper sericin (Cu-SER) metal–organic frameworks (MOFs) are reported. Sericin, a silk protein with antibacterial activity and an osteoinduction property, acts as an organic template for the deposition of Cu-SER MOFs, similar to collagen during biomineralization in bone. The MOFs exhibit cytocompatibility and osteogenic activity in a dose-dependent manner, as revealed by cell proliferation (alamarBlue) and mineralization (Alizarin Red S and Energy Dispersive X-ray analysis). The bactericidal activity of Cu-SER MOFs was investigated by scanning electron microscopy and a growth kinetic analysis. Together, the report illuminates the unique phenomenon of Cu-SER MOFs that kill bacteria upon contact while being well-tolerated by primary human cells. Hence, Cu-SER MOFs hold the potential to minimize antibiotic dependence. |
Journal | Biomimetics |
Volume | 7 |
Edition | 2 |
Issue | 64 |
Date Published | 2022-03-20 |
Publisher | MDPI |
ISSN | 2313-7673 |
DOI | 10.3390/biomimetics7020064 |
URL | https://www.mdpi.com/2313-7673/7/2/64 |
Keywords | antibacterial activity, Copper, Metal–organic framework, osteogenesis, Silk sericin |
Rights | openAccess |
Peer reviewed | yes |
Status | published |