Biological performance of a promising Kefiran-biopolymer with potential in regenerative medicine applications: a comparative study with hyaluronic acid

last updated: 2018-09-12
TitleBiological performance of a promising Kefiran-biopolymer with potential in regenerative medicine applications: a comparative study with hyaluronic acid
Publication TypePapers in Scientific Journals
Year of Publication2018
AuthorsRadhouani H., Gonçalves C., Maia F. R., Oliveira J. M., and Reis R. L.
Abstract

Kefiran from kefir grains, an exopolysaccharide (EPS) produced by lactic acid bacteria (LAB), has received an increasing interest because of its safe status. This natural biopolymer is a water-soluble glucogalactan with probed health-promoting properties. However, its biological performance has yet to be completely recognized and properly exploited. This research was carried out to evaluate the in vitro antioxidant and the in vitro anti-inflammatory properties of Kefiran biopolymer. Regarding antioxidant activity, the results demonstrated that the Kefiran extract possessed the strongest reducing power and superoxide radical scavenging, over hyaluronic acid (HA, gold standard viscosupplementation treatment). This exopolysaccharide showed a distinct antioxidant performance in the majority of in vitro working mechanisms of antioxidant activity comparing to HA. Moreover, Kefiran presented an interesting capacity to scavenge nitric oxide radical comparing to the gold standard that did not present any potency. Finally, the cytotoxic effects of Kefiran extracts on hASCs were also performed and demonstrated no cytotoxic response, ability to improve cellular function of hASCs. This study demonstrated that Kefiran represented a great scavenger for reactive oxygen and nitrogen species and showed also that it could be an excellent candidate to promote tissue repair and regeneration.

JournalJournal of Materials Science: Materials in Medicine
Volume29
Pagination124-134
Date Published2018-07-26
PublisherSpringer US
ISSN0957-4530
DOI10.1007/s10856-018-6132-7
URLhttps://link.springer.com/article/10.1007%2Fs10856-018-6132-7
KeywordsAnti-inflammatory activity, Antioxidant activity, Human adipose-derived stem cells, Kefiran polysaccharide, regenerative medicine.
RightsopenAccess
Peer reviewedno
Statuspublished

Back to top