Bioinspired Polyacrylic Acid-Based Dressing: Wet Adhesive, Self-Healing, and Multi-Biofunctional Coacervate Hydrogel Accelerates Wound Healing

last updated: 2024-02-27
TitleBioinspired Polyacrylic Acid-Based Dressing: Wet Adhesive, Self-Healing, and Multi-Biofunctional Coacervate Hydrogel Accelerates Wound Healing
Publication TypePapers in Scientific Journals
Year of Publication2023
AuthorsWang L. S., Duan L., Liu G., Sun J. F., Shahbazi M. A., Kundu S. C., Reis R. L., Xiao B., and Yang X.
Abstract

Polyacrylic acid (PAA) and its derivatives are commonly used as essential matrices in wound dressings, but their weak wet adhesion restricts the clinical application. To address this issue, a PAA-based coacervate hydrogel with strong wet adhesion capability is fabricated through a facile mixture of PAA copolymers with isoprenyl oxy poly(ethylene glycol) ether and tannic acid (TA). The poly(ethylene glycol) segments on PAA prevent the electrostatic repulsion among the ionized carboxyl groups and absorbed TA to form coacervates. The absorbed TA provides solid adhesion to dry and wet substrates via multifarious interactions, which endows the coacervate with an adhesive strength to skin of 23.4 kPa and 70% adhesion underwater. This coacervate achieves desirable self-healing and extensible properties suitable for frequently moving joints. These investigations prove that the coacervate has strong antibacterial activity, facilitates fibroblast migration, and modulates M1/M2 polarization of macrophages. In vivo hemorrhage experiments further confirm that the coacervate dramatically shortens the hemostatic time from hundreds to tens of seconds. In addition, full-thickness skin defect experiments demonstrate that the coacervate achieves the best therapeutic effect by significantly promoting collagen deposition, angiogenesis, and epithelialization. These results demonstrate that a PAA-based coacervate hydrogel is a promising wound dressing for medical translation.

JournalAdvanced Science
Volume10
Issue16
Date Published2023-04-14
PublisherWiley
ISSN2198-3844
DOI10.1002/advs.202207352
URLhttps://onlinelibrary.wiley.com/doi/full/10.1002/advs.202207352
KeywordsAntibacterial, polyacrylic acid, tannic acid, wet adhesion, Wound healing
RightsopenAccess
Peer reviewedyes
Statuspublished

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