Project | Cells4_IDs :: publications list |
Title | Biofunctionalized Liposomes to Monitor Rheumatoid Arthritis Regression Stimulated by Interleukin-23 Neutralization |
Publication Type | Papers in Scientific Journals |
Year of Publication | 2020 |
Authors | Lima, Ana C., Campos C. F., Cunha C., Carvalho A., Reis R. L., Ferreira H., and Neves N. M. |
Abstract | Even after the revolution of rheumatoid arthritis (RA) treatment with biologic agents, this debilitating disease remains a major clinical problem. The outstanding outcomes of the systemic administration of antibodies (Abs) are narrowed by the risk of serious side effects and limited efficacy due to their short half-life. Interleukin-23 (IL-23) is a crucial pro-inflammatory cytokine involved in inflammation that potently enhances the generation of T-helper type-17 (Th17) cells. Hence, in this work, anti-IL-23 Abs are immobilized at the surface of liposomes to increase their therapeutic efficacy, being gold nanoparticles (AuNPs) incorporated to allow monitoring the biodistribution of the liposomes after systemic administration as well as due to their anti-inflammatory and antioxidant effects. A stable monodispersed liposomes’ suspension with around 130 nm is produced and efficiently biofunctionalized |
Journal | Advanced Healthcare Materials |
Date Published | 2020-10-25 |
ISSN | 2192-2659 |
DOI | 10.1002/adhm.202001570 |
Keywords | anti-IL-23 antibodies, Gold nanoparticles, IL-17A inhibition, Liposomes, rheumatoid arthritis |
Rights | restrictedAccess |
Peer reviewed | yes |
Status | published |