Title | Bioactive Hydrogel Marbles |
Publication Type | Papers in Scientific Journals |
Year of Publication | 2018 |
Authors | Leite A. J., Oliveira N. M., Song W., and Mano J. F. |
Abstract | Liquid marbles represented a signifcant advance in the manipulation of fuids as they used particle flms to confne liquid drops, creating a robust and durable soft solid. We exploit this technology to engineering a bioactive hydrogel marble (BHM). Specifcally, pristine bioactive glass nanoparticles were chemically tuned to produce biocompatible hydrophobic bioactive glass nanoparticles (H-BGNPs) that shielded a gelatin-based bead. The designed BHM shell promoted the growth of a bone-like apatite layer upon immersion in a physiological environment. The fabrication process allowed the efcient incorporation of drugs and cells into the engineered structure. The BHM provided a simultaneously controlled release of distinct encapsulated therapeutic model molecules. Moreover, the BHM sustained cell encapsulation in a 3D environment as demonstrated by an excellent in vitro stability and cytocompatibility. The engineered structures also showed potential to regulate a pre-osteoblastic cell line into osteogenic commitment. Overall, these hierarchical nanostructured and functional marbles revealed a high potential for future applications in bone tissue engineering. |
Journal | Scientific Reports |
Volume | 8 |
Issue | 15215 |
Pagination | 1-11 |
Date Published | 2018-10-12 |
Publisher | Nature |
ISSN | 2045-2322 |
DOI | 10.1038/s41598-018-33192-6 |
URL | https://www.nature.com/articles/s41598-018-33192-6 |
Keywords | Bioactive nanoparticles, hydrogel, Marbles |
Rights | openAccess |
Peer reviewed | yes |
Status | published |