Project | 3BioMeD :: publications list |
Title | B-CULTURE – 4D human-based screening |
Publication Type | Comunication - Oral |
Year of Publication | 2019 |
Authors | Canadas R. F., Marques A. P., Oliveira J. M., and Reis R. L. |
Abstract | B-CULTUREoffers the BIOreACT system (figure 1) to the Pharma, Cosmetic and Medical Implants Industries as a solution for relevant preclinical product screening. Typically, drugs take 12 years to be licensed and the costs reach $1.5 billion[1]. In average, 87% of the molecules getting to the clinical trials are false positives due to low preclinical testing accuracy[2]. Notably, improving 10% in their prediction can save up $100 million/molecule[3]. In this regard, B-CULTURE technology enables a human-like 4D environment able to control and regulate two different but connected human-like tissues (e.g. bone-cartilage, dermis-epidermis, blood-brain sides,), granting no ethical concerns unlike animal models and realistic screening unlike the in vitro alternatives. Our first products-to-market are the skin and osteochondral models. Overall, we provide a solution for monitored realistic screening of medical products. |
Conference Name | SFB 2019 |
Date Published | 2019-04-05 |
Conference Location | Seattle, USA |
URL | https://2019.biomaterials.org/ |
Keywords | B-CULTURE, Business Plan, drug screening, osteochondral model |
Rights | openAccess |
Peer reviewed | yes |
Status | published |