Project | SPARTAN :: publications list |
Title | Advanced treatment for arthritic diseases based on the capture and inactivation of interleukin-6 by biofunctionalized polymeric nanoparticles |
Publication Type | Conference Abstract -ISI Web of Science Indexed |
Year of Publication | 2017 |
Authors | Lima, Ana C., Cunha C., Carvalho A., Ferreira H., and Neves N. M. |
Abstract | Arthritic diseases, such as osteoarthritis and rheumatoid arthritis, are associated with synovium inflammation (synovitis). Several pro-inflammatory cytokines, especially tumor necrosis factor-α (TNF-α) and interleukins (IL), are important mediators of inflammation and articular cartilage destruction, supporting a potential possibility of anticytokine therapy in these diseases. IL-6 is one of the key regulators of the inflammatory response. Thus, human monoclonal antibodies against IL-6 may prevent its action, and consequently reduce inflammation after intra-articular (IA) injection. Indeed, several clinical trials have already demonstrated positive outcomes over disease progression. Although these treatments are very attractive, they are associated with limited efficacy because of the rapid clearance of antibodies by the synovium. A solution to overcome this problem is using nanoparticles (NPs) as a substrate to protect and extend the action of the antibodies. Natural-derived polymers, like chitosan (Ch) and hyaluronic acid (HA), are biocompatible and biodegradable polysaccharides, being HA a natural component of the extracellular matrix of articular cartilage. Therefore, biodegradable polymeric NPs represent a good candidate for IA administration. |
Journal | European Cells and Materials |
Conference Name | TERMIS |
Volume | 33 |
Date Published | 2017-06-01 |
ISSN | 473-2262 |
Keywords | Arthritic diseases, Nanoparticles |
Rights | openAccess |
Peer reviewed | no |
Status | published |