Microfluidic production of hyaluronic acid derivative microfibers to control drug release

last updated: 2016-07-22
ProjectComplexiTE :: publications list
TitleMicrofluidic production of hyaluronic acid derivative microfibers to control drug release
Publication TypePapers in Scientific Journals
Year of Publication2016
AuthorsAgnello S., Gasperini L., Reis R. L., Mano J. F., Pitarresi G., Palumbo F. S., and Giammona G.
Abstract

Microfibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability oMicrofibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability of the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.f the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.

JournalMaterials Letters
Volume182
Pagination309-313
Date Published2016-11-01
PublisherElsevier
ISSN-
DOI10.1016/j.matlet.2016.07.014
URLhttp://www.sciencedirect.com/science/article/pii/S0167577X16311089
KeywordsBiomaterials, Drug delivery, Hyaluronic acid, microfibers, Microfluidic technique, Polymers
RightsclosedAccess
Peer reviewedyes
Statuspublished

Back to top