Title | Injectable biodegradable starch/chitosan delivery system for the sustained release of gentamicin to treat bone infections |
Publication Type | Papers in Scientific Journals |
Year of Publication | 2012 |
Authors | Balmayor E. R., Baran E. T., Azevedo H. S., and Reis R. L. |
Abstract | Starch-conjugated chitosan microparticles were produced aimed to be used as a carrier for the long term sustained/controlled release of antibiotic drugs to control bone infection. The microparticles were prepared by a reductive alkylation crosslinking method. The obtained microparticles showed a spherical shape, with a slightly rough and porous surface, and a size range of 80-150 mu m. Gentamicin was entrapped into the starch-conjugated chitosan microparticles and its release profile was studied in vitro. Increasing concentrations of gentamicin (from 50 to 150 mg/mL) led to a decrease in the encapsulation efficiency (from 67 to 55%), while drug loading increased from 4 to 27%. A sustained release of gentamicin was observed over a period of 30 days. The release kinetics could be controlled using an ionic crosslinker agent. In addition, a bacterial inhibition test on Staphylococcus aureus shows a diameter of the sample inhibition zone ranging from 12 to 17 mm (70-100% of relative activity). (C) 2011 Elsevier Ltd. All rights reserved. |
Journal | CARBOHYDRATE POLYMERS |
Volume | 87 |
Issue | 1 |
Pagination | 32-39 |
Date Published | 2012-01-04 |
Publisher | ELSEVIER SCI LTD |
ISSN | 0144-8617 |
DOI | 10.1016/j.carbpol.2011.06.078 |
Keywords | Gentamicin; Microparticles, Staphylococcus aureus, Starch-conjugated chitosan, Sustained release |
Rights | restrictedAccess |
Peer reviewed | yes |
Status | published |