Injectable biodegradable starch/chitosan delivery system for the sustained release of gentamicin to treat bone infections

last updated: 2013-02-12
TitleInjectable biodegradable starch/chitosan delivery system for the sustained release of gentamicin to treat bone infections
Publication TypePapers in Scientific Journals
Year of Publication2012
AuthorsBalmayor E. R., Baran E. T., Azevedo H. S., and Reis R. L.
Abstract

Starch-conjugated chitosan microparticles were produced aimed to be used as a carrier for the long term sustained/controlled release of antibiotic drugs to control bone infection. The microparticles were prepared by a reductive alkylation crosslinking method. The obtained microparticles showed a spherical shape, with a slightly rough and porous surface, and a size range of 80-150 mu m. Gentamicin was entrapped into the starch-conjugated chitosan microparticles and its release profile was studied in vitro. Increasing concentrations of gentamicin (from 50 to 150 mg/mL) led to a decrease in the encapsulation efficiency (from 67 to 55%), while drug loading increased from 4 to 27%. A sustained release of gentamicin was observed over a period of 30 days. The release kinetics could be controlled using an ionic crosslinker agent. In addition, a bacterial inhibition test on Staphylococcus aureus shows a diameter of the sample inhibition zone ranging from 12 to 17 mm (70-100% of relative activity). (C) 2011 Elsevier Ltd. All rights reserved.

JournalCARBOHYDRATE POLYMERS
Volume87
Issue1
Pagination 32-39
Date Published2012-01-04
PublisherELSEVIER SCI LTD
ISSN0144-8617
DOI10.1016/j.carbpol.2011.06.078
KeywordsGentamicin; Microparticles, Staphylococcus aureus, Starch-conjugated chitosan, Sustained release
RightsrestrictedAccess
Peer reviewedyes
Statuspublished

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