Dendrimer-based nanoparticles for intracellular delivery of drugs: Application in tissue engineering and regenerative medicine

Among the myriad of possibilities in bone tissue
engineering, the development novel strategies that can
stimulate stem cell differentiation to become osteoblasts
in the absence of typical osteogenic cocktails in vivo, it is
still regarded as a very appealing challenge. Recently, our
group has proposed a combinatorial strategy in tissue
engineering principles employing
carboxymethylchitosan/poly(amidoamine) dendrimer
nanoparticles (CMCht/PAMAM) towards the intracellular
release and regimented supply of dexamethasone (Dex)
aimed at control the rat bone marrow stromal cells
(RBMSCs) osteogenic differentiation, in vitro and in vivo.
In this work deeper studies on the physicochemical
properties and morphology of the nanoparticles were
carried out.