Controlled Release Strategies for Bone, Cartilage, and Osteochondral Engineering—Part II: Challenges on the Evolution from Single to Multiple Bioactive Factor Delivery

last updated: 2014-02-27
TitleControlled Release Strategies for Bone, Cartilage, and Osteochondral Engineering—Part II: Challenges on the Evolution from Single to Multiple Bioactive Factor Delivery
Publication TypePapers in Scientific Journals
Year of Publication2013
AuthorsSanto V. E., Gomes M. E., Mano J. F., and Reis R. L.
Abstract

 The development of controlled release systems for the regeneration of bone, cartilage, and osteochondral interface is one of the hot topics in the field of tissue engineering and regenerative medicine. However, the majority of the developed systems consider only the release of a single growth factor, which is a limiting step for the success of the therapy. More recent studies have been focused on the design and tailoring of appropriate combinations of bioactive factors to match the desired goals regarding tissue regeneration. In fact, considering the complexity of extracellular matrix and the diversity of growth factors and cytokines involved in each biological response, it is expected that an appropriate combination of bioactive factors could lead to more successful outcomes in tissue regeneration. In this review, the evolution on the development of dual and multiple bioactive factor release systems for bone, cartilage, and osteochondral interface is overviewed, specifically the relevance of parameters such as dosage and spatiotemporal distribution of bioactive factors. A comprehensive collection of studies focused on the delivery of bioactive factors is also presented while highlighting the increasing impact of platelet-rich plasma as an autologous source of multiple growth factors.

JournalTissue Engineering: Part B
Volume19
Issue4
Pagination327-352
Date Published2013-06-20
PublisherMary Ann Liebert, Inc.
DOI10.1089/ten.TEB.2012.0727
URLhttp://online.liebertpub.com/doi/abs/10.1089/ten.TEB.2012.0727?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
Keywordscontrolled release, tisssue engineering
RightsrestrictedAccess
Peer reviewedyes
Statuspublished

Back to top