Chitosan - Alginate multilayered films with gradients of physical cues

last updated: 2014-11-13
ProjectN/A :: publications list
TitleChitosan - Alginate multilayered films with gradients of physical cues
Publication TypeConference Abstract -ISI Web of Science Indexed
Year of Publication2014
AuthorsSilva J. M., Oliveira N. M., Reis R. L., and Mano J. F.

In general cell types are sensitive to mechanical stimulus of the surrounding environment which affects several cell properties. Thus, the development of biocompatible coatings with tuned mechanical properties are a current challenge, since gradients of physical signals are often applied in cellular processes to reconstruct the complex anisotropic environment presented by extracellular matrix (ECM) (1,2). Layer-by-layer (LbL) appears as a powerful tool since it allows the development of biomimetic multilayer films with well–controlled structures at both the nano and micro-scales (2). This study aimed to develop chitosan (CHIT) and alginate (ALG) polyelectrolyte multilayers with gradients of physical cues generated by changing the reaction time of
genipin crosslinking as a function of controlled distance.

JournalJournal of Tissue Engineering and Regenerative Medicine
Conference NameTERMIS-EU Meeting 2014
Date Published2014-06-10
Conference LocationGenova (Italy)
Keywordsgradients, LbL multilayer assemblies
Peer reviewedno

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