Bacterial Cellulose Membranes Constitute Biocompatible Biomaterials for Mesenchymal and Induced Pluripotent Stem Cell Culture and Tissue Engineering

last updated: 2013-11-05
TitleBacterial Cellulose Membranes Constitute Biocompatible Biomaterials for Mesenchymal and Induced Pluripotent Stem Cell Culture and Tissue Engineering
Publication TypePapers in Scientific Journals
Year of Publication2012
AuthorsOliveira C. R., Carvalho J. L., Novikoff S., Berti F. V., Porto L. M., Gomes D. A., and Goes A. M.
Abstract

Tissue engineering refers to an “interdisciplinary field that applies the principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function. In order to develop such biological substitutes, non-immunogenic cells, signaling molecules and scaffolds are required in large scale. In animal models of bone injury, for instance, up to 105-106 cells may be used in tissue engineering strategies. Considering the translation of such techniques to human proportions, the number of cells required for tissue engineering may reach up to a hundred million cells. Currently, adult stem cells are being used for such situations, mostly in clinical trial settings, and results are encouraging. Unfortunately, though, many limitations still hinder adult stem cell therapy. Induced Pluripotent Stem (iPS) Cell technology, which has recently crowned its inventor with a Noble Prize, holds great promise as a potential platform for generating cells for regenerative medicine purposes, able to attend the unmet need of tissue engineering, which requires large scale production of non immunogenic cells.

JournalTissue Science & Engineering
Date Published2012-11-08
ISSN2157-7552 JTSE
Keywordsbacterial celulose, Induced Pluripotent Stem (iPS).
RightsopenAccess
Peer reviewedyes
Statuspublished

Back to top