Title | Assembling human Platelet Lysate into Multiscale 3D Scaffolds for Bone Tissue Engineering |
Publication Type | Papers in Scientific Journals |
Year of Publication | 2014 |
Authors | Oliveira S. M., Reis R. L., and Mano J. F. |
Abstract | Scaffolds for bone tissue engineering lack often control of cellular instructions. We propose a triple sequential approach for customizing scaffold features from the macro to the nanoscale. The nano/meso-scale is composed by human platelet lysate and marine-origin polysaccharides assembled by layer-by-layer and shaped into fibrils by freeze-drying. We show that osteogenic induction of stem cells is tunable within a low range of layers. This approach has the potential to develop new scaffolds with enhanced cell-instructive capabilities using affordable autologous sources of bioactive molecules. |
Journal | ACS Biomaterials Science & Engineering |
Volume | 1 |
Edition | 1 |
Issue | 1 |
Pagination | 2-6 |
Date Published | 2014-11-21 |
Publisher | ACS |
DOI | DOI: 10.1021/ab500006x |
URL | http://pubs.acs.org/doi/abs/10.1021/ab500006x |
Keywords | bone, carrageenan, layer-by-layer, multiscale, Platelet lysate, sulfated polysaccharides |
Rights | embargoedAccess (2 Years) |
Peer reviewed | yes |
Status | published |