Assembling human Platelet Lysate into Multiscale 3D Scaffolds for Bone Tissue Engineering

last updated: 2015-01-14
TitleAssembling human Platelet Lysate into Multiscale 3D Scaffolds for Bone Tissue Engineering
Publication TypePapers in Scientific Journals
Year of Publication2014
AuthorsOliveira S. M., Reis R. L., and Mano J. F.
Abstract

Scaffolds for bone tissue engineering lack often control of cellular instructions. We propose a triple sequential approach for customizing scaffold features from the macro to the nanoscale. The nano/meso-scale is composed by human platelet lysate and marine-origin polysaccharides assembled by layer-by-layer and shaped into fibrils by freeze-drying. We show that osteogenic induction of stem cells is tunable within a low range of layers. This approach has the potential to develop new scaffolds with enhanced cell-instructive capabilities using affordable autologous sources of bioactive molecules.

JournalACS Biomaterials Science & Engineering
Volume1
Edition1
Issue1
Pagination2-6
Date Published2014-11-21
PublisherACS
DOIDOI: 10.1021/ab500006x
URLhttp://pubs.acs.org/doi/abs/10.1021/ab500006x
Keywordsbone, carrageenan, layer-by-layer, multiscale, Platelet lysate, sulfated polysaccharides
RightsembargoedAccess (2 Years)
Peer reviewedyes
Statuspublished

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