@article {20509,
	title = {Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models},
	journal = {Cancer Letters},
	volume = {504},
	year = {2021},
	month = {2021-04-28 00:00:00},
	pages = {116-124},
	publisher = {Elsevier},
	abstract = {<p>Tissue engineered organoids are simple biomodels that can emulate the structural and functional complexity of specific organs. Here, we review developments in three-dimensional (3D) artificial cell constructs to model<br>gastrointestinal dynamics towards cancer diagnosis. We describe bottom-up approaches to fabricate close-packed cell aggregates, from the use of biochemical and physical cues to guide the self-assembly of organoids, to the use of engineering approaches, including 3D printing/additive manufacturing and external field-driven protocols. Finally, we outline the main challenges and possible risks regarding the potential translation of gastrointestinal organoids from laboratory settings to patient-specific models in clinical applications.</p>},
	keywords = {bioengineering, Externally driven assembly, Organ on a chip, personalized medicine, self-assembly},
	issn = {0304-3835},
	doi = {10.1016/j.canlet.2021.01.023},
	url = {https://www.sciencedirect.com/science/article/pii/S0304383521000471?via\%3Dihub},
	author = {Soto, F. and Guimar{\~a}es, C. F. and Reis, R. L. and Franco, W. and Rizvi, I. and Demirci, U.}
}
