@article {20412, title = {Synthesis of mussel-inspired poly(dopamine)-gallium nanoparticles for biomedical applications}, journal = {Nanomedicine}, year = {2021}, month = {2021-01-07 00:00:00}, publisher = {Future Medicine}, abstract = {

Aim: In this work, we established a simple, controlled, and reproducible method to synthesize gallium-coated polydopamine (PDA) nanoparticles. Methods: Polydopamine was synthetized in the alkali medium with posterior gallium shell formation due to ion chelation on the nanoparticle surface. Results: The obtained results with EDS spectra confirmed the incorporation of gallium on PDA surface. The cytotoxicity of Ga-coated PDA nanoparticles was evaluated in vitro at different concentrations in contact with human adipose-derived stem cells (hASCs). Further cell analysis also demonstrated the benefit of Ga-coated PDA, which increased the cell proliferation rate compared to non-coated PDA. Conclusion: This study indicated that gallium could work as an appropriate shell for PDA particles, inducing cell proliferation at the analyzed concentrations.

}, keywords = {core/shell, cytotoxicity, gallium incorporation, nanoparticle synthesis}, issn = {1743-5889}, doi = {10.2217/nnm-2020-0312}, url = {https://www.futuremedicine.com/doi/10.2217/nnm-2020-0312}, author = {Teixeira, J. V. U. and Maia, F. R. and Carvalho, M. R. and Reis, R. L. and Oliveira, J. M. and Lisboa-Filho, P. N. and Claro, A. P. R. A.} }