@inbook {20277,
	title = {Designing microenvironments for optimal outcomes in tissue engineering and regenerative medicine: From biopolymers to culturing conditions},
	booktitle = {Encyclopedia of Tissue Engineering and Regenerative Medicine},
	year = {2019},
	month = {2019-06-03 00:00:00},
	pages = {119-30},
	publisher = {Academic Press},
	organization = {Academic Press},
	abstract = {<p>Bone marrow mesenchymal stem cells have been extensively used for tissue engineering and regenerative medicine applications due to their ease of isolation and expansion and their ability to differentiate towards various lineages of mesodermal origin. Despite these properties, their clinical potential is often hampered by the simplicity of the in vitro environment and its inability to resemble the complex in vivo niche. Herein, different microenvironmental cues (e.g. surface topography, substrate stiffness, mechanical stimulation, oxygen tension and co-culture systems) that have been utilised to enhance the therapeutic efficacy of bone marrow mesenchymal stem cells are discussed.</p>},
	keywords = {Microenvironmental cues, Surface topography, Tissue engineering},
	isbn = {9780128136997},
	url = {https://www.elsevier.com/books/encyclopedia-of-tissue-engineering-and-regenerative-medicine/reis/978-0-12-813699-7},
	author = {Tsiapalis, D. and Ribeiro, S. and De Pieri, A. and Sallent, I. and Guillaumin, S. and Gaspar, D. and Korntner, S. and Bayon, Y. and Gomes, M. E. and Reis, R. L. and Zeugolis, D. I.},
	editor = {Reis, R. L. and Gomes, M. E.}
}
