@article {20246, title = {Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure}, journal = {Chemical Communications}, volume = {56}, year = {2020}, month = {2020-02-10 00:00:00}, pages = {3187-3190}, publisher = {The Royal Society of Chemistry}, abstract = {

The isomers vescalagin and castalagin protect SH-SY5Y cells from Aβ42-mediated death. This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 position of the glycosidic chain, improving its capacity to remodel the secondary structure of toxic Aβ42 oligomers.

}, keywords = {Alzheimer{\textquoteright}s disease, amyloid-beta, natural polyphenols}, issn = {1359-7345}, doi = {10.1039/D1CC90090K}, url = {https://pubs.rsc.org/en/content/articlehtml/2020/cc/d0cc00192a}, author = {Ara{\'u}jo, A. R. and Gigante, S. C. and Taboada, P. and Reis, R. L. and Pires, R. A.} }