@article {20227, title = {Mechanosensing of neurons in 3D brain surrogate}, journal = {Stanford Bio-X 2017}, year = {2017}, month = {2017-10-03 00:00:00}, address = {Stanford, USA}, abstract = {

The replication of the complex structure and\ three dimensional\ (3-D)\ interconnectivity\ of\ neurons\ in the brain is a great challenge. A few 3-D neuronal patterning approaches have been developed to mimic the\ cell distribution\ in the brain but none have demonstrated the relationship between 3-D neuron patterning and\ network connectivity. Here, we used photolithographic crosslinking to fabricate\ in vitro\ 3-D neuronal structures with distinct sizes, shapes or interconnectivity, i.e., milli-blocks, micro-stripes, separated micro-blocks and connected micro-blocks, which have spatial confinement from {\textquotedblleft}Z{\textquotedblright} dimension.

}, keywords = {hydrogel, Mechanosensing, Neural model}, url = {https://biox.stanford.edu/event/fellows-symposium-october-2017}, author = {Ren, T. and Karaca, E. and Canadas, R. F. and Demirci, U.} }