@article {20078, title = {Enzymatically-crosslinked Silk Fibroin Hydrogels as Platforms for Cancer Therapeutic Strategies}, journal = {1st Discoveries Forum on Regenerative and Precision Medicine}, year = {2019}, month = {2019-09-25 00:00:00}, address = {Porto Pal{\'a}cio Congress Hotel \& Spa, Porto, Portugal}, abstract = {

In recent years, in vitro tumour models are used to unveil novel therapeutic strategies for anti-cancer formation and development (1). A novel technique, called irreversible electroporation (IRE), recently showed promising applications as cancer therapy treatment (2,3). The aim of this work is to test the conductivity of newly generated enzymatically-crosslinked silk fibroin (SF) hydrogels, which spontaneously acquire SF conformational change from random-coil to β-sheet during time (4,5). The preliminary obtained results show that SF hydrogels{\textquoteright} conductivity progressively decreases during time, phenomenon concomitant with the SF conformational transition. Overall, these findings support the further development and use of these hydrogels as anti-tumor therapy platforms.

Acknowledgments: This work has been funded under the COST action BIONECA (CA16122 - Biomaterials and advanced physical techniques for regenerative cardiology and neurology) and supported by the European Cooperation in Science \& Technology (COST).

References

1) Hinderer, S. et al. Adv. Drug Deliv. Rev. 97, 260{\textendash}269 (2016).

2) Garcia, P. A. et al. Technol. Cancer Res. Treat. 10, 73{\textendash}83 (2011).

3) Neal, R. E. et al. J. Clin. Oncol. 29, e372{\textendash}e377 (2011).

4) Yan, L. et al. Patent PT 107426. (2014).

5) Yan, L.-P. et al. Sci. Rep. 6, 31037 (2016).

}, keywords = {Cancer, Hydrogels, Silk Fibroin, Therapies}, author = {Pierantoni, L. and Oliveira, J. M. and Reis, R. L. and Nandi, R. and Agam, Y. and Amdursky, N.} }