@article {20055, title = {Chitosan films with varying degrees of acetylation for application in peripheral nerve regeneration}, journal = {TermStem}, year = {2016}, month = {2016-01-22 00:00:00}, abstract = {

Damage to the Peripheral Nervous System (PNS) is\ remarkably common and occurs mainly as a result\ from trauma or complications of surgery [1]. Although\ recovery of nerve function occurs in some mild
injuries, outcomes are frequently poor following\ severe trauma, resulting in long-term impairment of
limb function, dysaesthesia and pain, often with\ associated psychological effects [2]. As consequence,
this issue has been raising major concerns in\ regenerative medicine for several years as\ unsatisfactory recovery continues to be a significant\ clinical challenge [3].\ Chitosan, because of its good biocompatibility and physicochemical properties has\ been proposed as a biomaterial for tackling peripheral nerve injuries. The Degree of\ Acetylation (DA) is a key parameter that can be controlled and has a major impact on\ material properties. According to the literature, decreasing DA leads to greater\ Schwann cell adhesion [4].

}, keywords = {cell adhesion, Chitosan, nerve repair, Schwann cells}, author = {Carvalho, C. R. and L{\'o}pez-Cebral, R. and Silva-Correia, J. and Silva, J. M. and Mano, J. F. and Silva, T. H. and Freier, T. and Reis, R. L. and Oliveira, J. M.} }