@article {19910, title = {Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo}, journal = {Carbohydrate Polymers}, volume = {223}, year = {2019}, month = {2019-06-28 00:00:00}, publisher = {Elsevier}, abstract = {

Fucoidan is a marine-origin sulfated polysaccharide that can show anticancer activity, to which both pro- and anti-angiogenic responses have been reported. Due to this unpredictability, the angiogenic potential of an effective anticancer crude fucoidan (CF), at a concentration of 0.5 mg mL-1, was evaluated. Tube formation assays demonstrated that CF, either administered while endothelial cells seeding or after their adhesion, migration and organization, inhibited or disrupted the formation of tubular-like structures, respectively. Although CF did not significantly reduced vascular endothelial growth factor (VEGF) secretion, it significantly reduced the expression of platelet-derived growth factor (PDGF), compromising the blood vessels maturation. Two chicken embryo chorioallantoic membrane (CAM) assays were performed: one without tumor (CAM I) and the other with an onplanted tumor mass (CAM II); the CF injection reduced the number of blood of vessels and significantly decreased the tumor size, respectively.\ In vitro\ and\ in vivoresults support the effectiveness of fucoidan as a natural antitumor therapeutic agent.

}, keywords = {Angiogenesis, Anticancer, Fucoidan, Tumor}, issn = {0144-8617}, doi = {10.1016/j.carbpol.2019.115034}, url = {https://www.sciencedirect.com/science/article/pii/S0144861719307015}, author = {Oliveira, C. and Granja, S. and Neves, N. M. and Reis, R. L. and Baltazar, F. and Silva, T. H. and Martins, A.} }