@article {19882, title = {Kefiran cryogels as potential scaffolds for drug delivery and tissue engineering applications}, journal = {Materials Today Communications}, year = {2019}, month = {2019-06-25 00:00:00}, pages = {100554}, publisher = {Elsevier}, abstract = {
A Kefiran-based scaffold was developed using a freeze gelation technique, and its potential use for both drug delivery system and tissue engineering applications were investigated. This scaffold showed, through micro-computed tomography and scanning electron microscopy, high porosity (82.3 {\textpm} 4.4\%), thick pore walls (13.4 {\textpm} 0.7 μm), aerogel form with foam-like structure, and elastic behaviour (δ = 16 {\textpm} 0.7{\textordmasculine}). Moreover, the Kefiran scaffold degradation showed a delayed profile for over 28 days. The developed scaffold allowed a slow and sustained diclofenac release over two weeks, and the human Adipose-derived Stem Cells, cultured onto the Kefiran scaffold, were metabolically active after 72 h. Therefore, our research suggests that Kefiran cryogel could be a potential candidate for drug delivery of controlled bioactive molecules and tissue engineering scaffolding.
}, keywords = {diclofenac, Drug Delivery System, Kefiran cryogels, scaffolds, Tissue engineering}, issn = {2352-4928}, doi = {10.1016/j.mtcomm.2019.100554}, url = {https://www.sciencedirect.com/science/article/pii/S2352492818303064$\#$abs0015}, author = {Radhouani, H. and Bicho, D. and Gon{\c c}alves, C. and Maia, F. R. and Reis, R. L. and Oliveira, J. M.}, editor = {De Geuser, F. and Giebeler, L. and Humphry-Baker, S. and Martin, T. and Miquelard-Garnier, G.} }