@article {19858,
	title = {Micro-CT - A Digital 3D Microstructural Voyage into Scaffolds: A Systematic Review of the Reported Methods and Results},
	journal = {Biomaterials Research },
	year = {2018},
	month = {2018-09-26 00:00:00},
	abstract = {<p><span>Background: Cell behavior is the key to tissue regeneration. Given the fact that most of the cells used in tissue engineering are anchorage-dependent, their behavior including adhesion, growth, migration, matrix synthesis, and differentiation is related to the design of the scaffolds. Thus, characterization of the scaffolds is highly required. Micro-computed tomography (micro-CT) provides a powerful platform to analyze, visualize, and explore any portion of interest in the scaffold in a 3D fashion without cutting or destroying it with the benefit of almost no sample preparation need. Main body: This review highlights the relationship between the scaffold microstructure and cell behavior, and provides the basics of the micro-CT method. In this work, we also analyzed the original papers that were published in 2016 through a systematic search to address the need for specific improvements in the methods section of the papers including the amount of provided information from the obtained results.</span></p>},
	keywords = {Microstructure, Mineral density, scaffolds, Systematic review, Tissue engineering},
	issn = {2055-7124},
	doi = {10.1186/s40824-018-0136-8},
	author = {Cengiz, I. F. and Oliveira, J. M. and Reis, R. L.}
}
