@inbook {19586,
	title = {PRP Therapy},
	booktitle = {Osteochondral Tissue Engineering},
	year = {2018},
	month = {2018-05-08 00:00:00},
	publisher = {Springer},
	organization = {Springer},
	chapter = {11},
	abstract = {<p><span>Osteochondral lesions remain as a clinical challenge despite the advances in orthopedic regenerative strategies. Biologics, in particular, platelet-rich plasma, has been applied for the reparative and regenerative effect in many tissues, and osteochondral tissue is not an exception. Platelet-rich plasma is an autologous concentrate prepared from the collected blood; thus, this safe application is free of immune response or risk of transmission of disease. It has a high potential to promote regeneration, thanks to its content, and can be applied alone or can reinforce a tissue engineering strategy. The relevant works making use of platelet-rich plasma in osteochondral lesions are overviewed herein. The practical success of platelet-rich plasma is uncertain since there are many factors involved including but not limited to its preparation and administration method. Nevertheless, today, the issues and challenges of platelet-rich plasma have been well acknowledged by researchers and clinicians. Thus, it is believed that a consensus will be built it, and then with high-quality randomized controlled trials and standardized protocols, the efficacy of platelet-rich plasma therapy can be better evaluated.</span></p>},
	keywords = {Osteochondral, Platelet-Rich Plasma, regeneration, Tissue engineering},
	doi = {10.1007/978-3-319-76735-2_11},
	url = {https://link.springer.com/chapter/10.1007/978-3-319-76735-2_11},
	author = {Cengiz, I. F. and Oliveira, J. M. and Reis, R. L.},
	editor = {Oliveira, J. M. and Pina, S. and Reis, R. L. and Roman, J. S.}
}
