@article {19314,
	title = {Wetspun poly-L-(lactic acid)-borosilicate bioactive glass scaffolds for guided bone regeneration},
	journal = {Materials Science and Engineering C},
	volume = {71},
	year = {2017},
	month = {2017-02-01 00:00:00},
	pages = {252-259},
	publisher = {Elsevier},
	abstract = {<p>We developed a porous Poly-L-Lactic Acid (PLLA) scaffold compounded with borosilicate bioactive glasses (BBGs) endowing it with bioactive properties. Porous PLLA-BBGs fibre mesh scaffolds were successfully prepared by the combination of wet spinning and fibre bonding techniques. Micro-computed tomography ({\textmu}CT) confirmed that the PLLA-BBG scaffolds containing ≈ 25\% of BBGs (w/w) exhibited randomly interconnected porous (58 to 62\% of interconnectivity and 53 to 67\% of porosity) with mean pore diameters higher that 100 {\textmu}m. Bioactivity and degradation studies were performed by immersing the scaffolds in simulated body fluid (SBF) and ultrapure water, respectively. The PLLA-BBG scaffolds presented a faster degradation rate with a constant release of inorganic species, which are capable to produce calcium phosphate structures at the surface of the material after 7 days of immersion in SBF (Ca/P ratio of ~1.7). Cellular <em>in vitro</em> studies showed that PLLA-BBGs are not cytotoxic to cells, while demonstrating their capacity to promote cell adhesion and proliferation. Overall, we showed that the proposed scaffolds present a tailored kinetics on the release of inorganic species and controlled biological response under conditions that mimic the bone physiological environment.</p>},
	keywords = {Borosilicate bioactive glasses, Poly-L-lactic acid},
	issn = {0928-4931},
	doi = {10.1016/j.msec.2016.10.007},
	url = {https://www.sciencedirect.com/science/article/pii/S0928493116316526},
	author = {Fernandes, J. S. and Reis, R. L. and Pires, R. A.}
}
