@article {18836,
	title = {Molecularly imprinted intelligent scaffolds for tissue engineering applications},
	journal = {Tissue Engineering Part B: Reviews.},
	volume = {23},
	year = {2017},
	month = {2017-02-01 00:00:00},
	pages = {27-43},
	publisher = {Mary Ann Liebert},
	abstract = {<p>The development of molecularly imprinted polymers (MIPs) using biocompatible production methods enables the\&nbsp;possibility to further exploit this technology for biomedical applications. Tissue engineering (TE) approaches\&nbsp;use the knowledge of the wound healing process to design scaffolds capable of modulating cell behavior and\&nbsp;promote tissue regeneration. Biomacromolecules bear great interest for TE, together with the established recognition\&nbsp;of the extracellular matrix, as an important source of signals to cells, both promoting cell{\textendash}cell and cell{\textendash}matrix interactions during the healing process. This review focuses on exploring the potential of protein molecular\&nbsp;imprinting to create bioactive scaffolds with molecular recognition for TE applications based on the most recent\&nbsp;approaches in the field of molecular imprinting of macromolecules. Considerations regarding essential components\&nbsp;of molecular imprinting technology will be addressed for TE purposes. Molecular imprinting of biocompatible\&nbsp;hydrogels, namely based on natural polymers, is also reviewed here. Hydrogel scaffolds with molecular\&nbsp;memory show great promise for regenerative therapies. The first molecular imprinting studies analyzing cell adhesion\&nbsp;report promising results with potential applications for cell culture systems, or biomaterials for implantation\&nbsp;with the capability for cell recruitment by selectively adsorbing desired molecules.</p>},
	keywords = {intellengent scaffolds, Molecular imprinting, Tissue engineering},
	issn = {2152-4947},
	doi = {10.1089/ten.teb.2016.0202},
	author = {Neves, M. I. and Wechsler, M. E. and Gomes, M. E. and Reis, R. L. and Granja, P. L. and Peppas, N. A.}
}
