@article {18714, title = {In vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing}, journal = {Nanomedicine}, year = {2016}, month = {2016-04-14 00:00:00}, pages = {1}, publisher = {Future Medicine}, abstract = {

Aim: To expand our understanding on the effect of magnetically actuated biomaterials in stem cells, inflammation and fibrous tissue growth. Materials \& methods: Magnetic biomaterials were obtained by doping iron oxide particles into starch poly-ϵ-caprolactone (SPCL) to create two formulations, magSPCL-1.8 and 3.6. Stem cell behavior was assessed in vitro and the inflammatory response, subcutaneously in Wistar rats. Results: Metabolic activity and proliferation increased significantly overtime in SPCL and magSPCL-1.8. Electromagnetic fields attenuated the presence of mast cells and macrophages in tissues surrounding SPCL and magSPCL-1.8, between weeks 1 and 9. Macrophage reduction was more pronounced for magSPCL-1.8, which could explain why this material prevented growth of fibrous tissue overtime. Conclusion: Magnetically actuated biomaterials have potential to modulate inflammation and the growth of fibrous tissue.

}, keywords = {Fibrous adhesions, Magnetic biomaterials, Tendon healing/repair}, issn = {1743-5889}, doi = {10.2217/nnm-2015-0014}, url = {http://www.futuremedicine.com/doi/abs/10.2217/nnm-2015-0014}, author = {Santos, L. and Silva, M. and Gon{\c c}alves, A. I. and Pesqueira, T. and Rodrigues, M. T. and Gomes, M. E.} }