@inproceedings {18502,
	title = {Tendon Regeneration Through a Scaffold-free Approach: Development of Tenogenic Magnetic hASCs Sheets},
	journal = {TISSUE ENGINEERING: Part A},
	volume = {21},
	year = {2015},
	month = {2015-08-28 00:00:00},
	pages = {S-357},
	address = {Boston, Massachusetts},
	abstract = {<p style="text-align: justify;">Tendon{\textquoteright}s regeneration is limited, demanding for cell-based strategies to fully restore their functionality upon injury. The concept of magnetic force-based TE(1), generally using magnetic nanoparticles may enable, for example, stem cell stimulation and/or remote control over TE constructs. Thus, we originally propose the development of magnetic cell sheets (magCSs) with tenogenic capability, aimed at promoting tendon{\textquoteright}s regeneration.</p>
<p style="text-align: justify;">A Tenomodulin (TNMD+) subpopulation was sorted from human adipose stem cells (hASCs), using TNMD-coated immunomagnetic beads(2) and used as cell source for the development of magCSs. Briefly, cells were labeled with iron oxide composite particles (Micromod) and cultured for 7 days in α-MEM medium with or without magnetic stimulation provided by a magnetic device (nanoTherics). CSs were retrieved from the plates using magnet attraction as contiguous sheets of cells within its own deposited ECM.</p>},
	keywords = {hASCs, Scaffold-free, Tendon},
	doi = {10.1089/ten.tea.2015.5000.abstracts},
	author = {Gon{\c c}alves, A. I. and Rodrigues, M. T. and Reis, R. L. and Gomes, M. E.}
}
