@article {18473,
	title = {Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology},
	journal = {International Journal of Pharmaceutics},
	volume = {492},
	year = {2015},
	month = {2015-07-17 00:00:00},
	pages = {73-79},
	publisher = {PubMed Commons},
	abstract = {<p>Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-e-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt\%), after supercritical fluid sintering at 20 MPa and 50 C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and microcomputed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds.</p>},
	keywords = {Biodegradable polymers, Drug delivery systems, Ibuprofen, Supercritical carbon dioxide, Therapeutic deep eutectic solvents},
	issn = {0378-5173},
	doi = {10.1016/j.ijpharm.2015.06.038},
	url = {www.ncbi.nlm.nih.gov/pubmed/26142248},
	author = {Aroso, I. M. and Craveiro, R. and Rocha, A. and Dionisio, M. and Barreiros, S. and Reis, R. L. and Paiva, A. and Duarte, A. R. C.}
}
