@article {18231,
	title = {Assembling human Platelet Lysate into Multiscale 3D Scaffolds for Bone Tissue Engineering},
	journal = {ACS Biomaterials Science \& Engineering},
	volume = {1},
	year = {2014},
	month = {2014-11-21 00:00:00},
	pages = {2-6},
	publisher = {ACS},
	edition = {1},
	abstract = {<p><span>Scaffolds for bone tissue engineering lack often control of cellular instructions. We propose a triple sequential approach for customizing scaffold features from the macro to the nanoscale. The nano/meso-scale is composed by human platelet lysate and marine-origin polysaccharides assembled by layer-by-layer and shaped into fibrils by freeze-drying. We show that osteogenic induction of stem cells is tunable within a low range of layers. This approach has the potential to develop new scaffolds with enhanced cell-instructive capabilities using affordable autologous sources of bioactive molecules.</span></p>},
	keywords = {bone, carrageenan, layer-by-layer, multiscale, Platelet lysate, sulfated polysaccharides},
	doi = {DOI: 10.1021/ab500006x},
	url = {http://pubs.acs.org/doi/abs/10.1021/ab500006x},
	author = {Oliveira, S. M. and Reis, R. L. and Mano, J. F.}
}
