@article {18167,
	title = {Polycaprolactone membranes reinforced by toughened sol-gel produced silica networks},
	journal = {Journal of Sol-Gel Science and Technology},
	volume = {71},
	year = {2014},
	month = {2014-04-02 00:00:00},
	pages = {136-146},
	publisher = {Springer},
	abstract = {<p style="text-align: justify;"><span>The aim of this work is to develop polycaprolactone based porous materials with improved mechanical performance to be used in bone repair. The hybrid membranes consist in a polymeric porous material in which the pore walls are coated by a silica thin layer. Silica coating increases membrane stiffness with respect to pure polymer but in addition filling the pores of the polymer with a silica phase improves bioactivity due to the delivery of silica ions in the neighborhood of the material in vivo. Nevertheless silica network, even that produced by sol{\textendash}gel, might be too stiff and brittle what is not desirable for its performance as a coating. In this work we produced a toughened silica coating adding chitosan and 3-glycidoxypropyltrimethoxysilane (GPTMS) to the precursor solution looking for having polymer chains linked by covalent bonding to the silica network. Hybrid polymer{\textendash}silica coating was produced by in situ sol{\textendash}gel reaction using Tetraethyl orthosilicate (TEOS), GPTMS and chitosan. Chemical reaction between amine groups of chitosan chains and epoxy groups of GPTMS allowed covalent bonding of polymer chains to the silica network. Physical properties of the hybrid membranes were characterized and cell attachment of MC3T3-E1 pre-osteoblastic cells on the surface of these supports was assessed.</span></p>},
	keywords = {Biodegradable biomaterials, Bone Tissue Engineering, Chitosan, polycaprolactone, Silica coating, Sol{\textendash}gel},
	doi = {10.1007/s10971-014-3342-4},
	url = {http://link.springer.com/article/10.1007/s10971-014-3342-4},
	author = {Trujillo, S. and Bonilla, C. E. P. and Santos, M. S. and Matos, J. M. and Gamboa, T. and Perilla, J. E. and Mano, J. F. and Ribelles, J. L. G.}
}
