@article {18036,
	title = {Internalization of Magnetic Iron Oxide Nanoparticles for Stem Cell Functionalization},
	journal = {Termis EU 2014},
	year = {2014},
	month = {2014-06-10 00:00:00},
	address = {Genova, Italy},
	abstract = {<p>Cell monitoring and cell localization can be potentially achieved by the internalization of magnetic nanoparticles (MNPs) in\&nbsp;the cells. This might allow for the investigation of migratory patterns through tracking studies, the targeting of particlelabelled\&nbsp;cells to desired locations via the application of an external magnetic field and, finally, for activation stem cells to\&nbsp;initiate desired cellular responses as inducing the differentiation process [1]. This study aims at determining the effect of\&nbsp;magnetic stimulation in human adipose stem cells (hASCs) differentiation towards tendon cells. Firstly, the MNPs uptake by\&nbsp;the cell and magnitude/frequency of the external magnetic field was verified. Afterwards, initial studies on understanding the\&nbsp;endocytic mechanisms involved in the uptake of MNPs were performed. For this, cells were treated with pharmacological\&nbsp;inhibitors before exposure to fluorescent labeled MNPs.</p>},
	keywords = {Magnetic nanoparticles, Stem cells},
	author = {Gon{\c c}alves, A. I. and Rodrigues, M. T. and Reis, R. L. and Gomes, M. E.}
}
