@inbook {17982,
	title = {Lessons from the Sea: Distribution, SAR and Molecular Mechanisms of Anti-inflammatory Drugs from Marine Organisms},
	booktitle = {Studies in Natural Products Chemistry (Bioactive Natural Products)},
	volume = {40},
	year = {2013},
	month = {2013-09-12 00:00:00},
	publisher = {Elsevier Science Publishers},
	organization = {Elsevier Science Publishers},
	abstract = {<p>Marine organisms have been increasingly regarded as excellent sources of new drugs for human therapeutics due to their remarkable chemistry, which in turn is reflected in their wide range of biological applications, including cancer, inflammation, infection and pain. In the last 20 years several new drugs have been discovered, some of them with novel pharmacological targets and the first sea-derived approved medicines are now paving their way into the market. In this review we will focus in small-molecule drugs obtained from marine animals (sponges, gorgonians, mollusks, echinoderms) for the treatment of inflammation. The distribution of these compounds by different taxonomical families will be discussed, as well as the state-of the-art regarding their structure-activity relationship. The most important chemical classes will be presented, such as terpenes, alkaloids, among others. The most important molecular targets, including phospholipase A<sub>2</sub> (PLA<sub>2</sub>), cyclooxygenases (COX), nitric oxide synthase (NOS) and NF-κB will be discussed.</p>},
	keywords = {Anti-inflammatory, drugs, marine},
	author = {Pereira, D. M. and Valent{\~a}o, P. and Andrade, P.},
	editor = {Atta-ur-Rahman, A.}
}
