@article {17903, title = {Chitosan/chondroitin sulfate multilayers as supports for calcium phosphate biomineralization}, journal = {Materials Letters}, volume = {121}, year = {2014}, month = {2014-04-15 00:00:00}, pages = {62-65}, publisher = {Elsevier}, abstract = {

We investigated the interaction of natural derived macromolecular multilayers with calcium and phosphate ions entirely processed using the layer-by-layer (LbL) technique. A nanostructured multilayer component, with 5 or 10 bilayers, was first produced using weak polyelectrolyte biopolymers, chitosan and chondroitin sulfate. This was followed by sequential passing of solutions containing Ca2+\ and\ PO43-\ over the multilayers. QCM-D, SEM and EDX results conferred the formation of calcium phosphate (CaP) over the polyelectrolyte multilayers. Initiation of precipitation was observed earlier in the 10 bilayers coating than in the 5 bilayers one. These results indicate the potential of multilayers to trap ions, as a biomimetic approach that can be used to induce CaP precipitation. This could enable the preparation of more performant bioactive composite biomaterials for orthopedic applications, including in bone tissue engineering.

}, keywords = {Biomaterials, Biomimetic, Multilayer structure, nanocomposites}, issn = {0167-577X}, doi = {10.1016/j.matlet.2014.01.099}, url = {http://dx.doi.org/10.1016/j.matlet.2014.01.099}, author = {Leite, A. J. and Sher, P. and Mano, J. F.} }