@article {17648,
	title = {Controlled Release Strategies for Bone, Cartilage, and Osteochondral Engineering-Part I: Recapitulation of Native Tissue Healing and Variables for the Design of Delivery Systems},
	journal = {TISSUE ENGINEERING: Part B},
	volume = {19},
	year = {2013},
	month = {2013-02-15 00:00:00},
	publisher = {Mary Ann Liebert, Inc.},
	abstract = {<p>The potential of growth factors to stimulate tissue healing through the enhancement of cell proliferation, migration,\&nbsp;and differentiation is undeniable. However, critical parameters on the design of adequate carriers, such\&nbsp;as uncontrolled spatiotemporal presence of bioactive factors, inadequate release profiles, and supraphysiological\&nbsp;dosages of growth factors, have impaired the translation of these systems onto clinical practice. This review\&nbsp;describes the healing cascades for bone, cartilage, and osteochondral interface, highlighting the role of specific\&nbsp;growth factors for triggering the reactions leading to tissue regeneration. Critical criteria on the design of carriersfor controlled release of bioactive factors are also reported, focusing on the need to provide a spatiotemporal\&nbsp;control over the delivery and presentation of these molecules.</p>},
	keywords = {bone cartilage, Drug delivery, Osteochondral, tissue engineering and regenerative medicine},
	doi = {10.1089/ten.teb.2012.0138},
	url = {http://online.liebertpub.com/doi/abs/10.1089/ten.teb.2012.0138},
	author = {Santo, V. E. and Gomes, M. E. and Mano, J. F. and Reis, R. L.}
}
