@article {17605, title = {Wettability Influences Cell Behavior on Superhydrophobic Surfaces with Different Topographies}, journal = {Biointerphases}, volume = {7}, year = {2012}, month = {2012-12-03 00:00:00}, publisher = {SPRINGER, 233 SPRING ST, NEW YORK, NY 10013 USA}, abstract = {

Surface\ wettability\ and topography are recognized as critical factors influencing\ cellbehavioron\ biomaterials. So far only few works have reported\ cell\ responses\ onsurfaces\ exhibiting extreme\ wettability\ in combination\ with\ surface topography. The goal of this work is to study whether\ cellbehavioronsuperhydrophobicsurfaces\ is influenced by surface topography and polymer type. Biomimetic\ superhydrophobic\ rough\ surfaces\ of polystyrene and poly(L-lactic acid)\ withdifferent\ micro/nanotopographies were obtained from smooth\ surfaces\ using a simple phase-separation based method. Total protein was quantified and showed a less adsorption of bovine serum albumin onto rough\ surfaces\ as compared to smooth\ surfaces\ of the same material. The mouse osteoblastic MC3T3-E1\ cell\ line and primary bovine articular chondrocytes were used to study\ cell\ attachment and proliferation. Cells attached and proliferate better in the smooth\ surfaces. The\ superhydrophobicsurfaces\ allowed cells to adhere but inhibited their proliferation. This study indicates that surface\ wettability, rather than polymer type or the topography of the\ superhydrophobicsurfaces, is a critical factor in determining\ cellbehavior.

}, keywords = {ATTACHMENT, BLOOD COMPATIBILITY, bone, fibronectin, INTERFACE, MICROTOPOGRAPHIES, Morphology, OSTEOBLAST ADHESION, POLY(L-LACTIC ACID), protein adsorption}, issn = {1934-8630}, doi = {10.1007/s13758-012-0046-6}, url = {http://apps.webofknowledge.com/full_record.do?product=UA\&search_mode=GeneralSearch\&qid=18\&SID=R26mYWbF6MIAgV5us3R\&page=1\&doc=1}, author = {Louren{\c c}o, B. N. and Marchioli, G. and Song, W. L. and Reis, R. L. and van Blitterswijk, C. A. and Karperien, M. and Mano, J. F.} }