@article {17448,
	title = {Association of the IL-10 polymorphisms and periodontitis: a meta-analysis},
	journal = {Molecular Biology Reports},
	volume = {39},
	year = {2012},
	month = {2012-07-12 00:00:00},
	pages = {9319-9329},
	publisher = {Springer Netherlands},
	abstract = {<p><span>No clear consensus has been reached regarding the association of IL-10 polymorphisms and periodontitis. Therefore, we performed a meta-analysis of case{\textendash}control studies and a systemic review in an effort to systematically summarize the existing knowledge. Studies were identified by searching PubMed database until December 2011. IL-10 -1082 (-1087) A\&gt;G, -819 (-824) C\&gt;T and -592 (-597) C\&gt;A polymorphisms were included in the present meta-analysis. We calculated the specific odds ratios along with their 95\&nbsp;\% confidence intervals to compare the distribution of alleles and genotypes between cases and controls. An additive {\textquotedblleft}per-allele{\textquotedblright} model (major allele vs. minor allele) was performed, and dominant and recessive models were also considered. The random-effects model was applied for the analysis. Cumulative analysis was also performed. Heterogeneity and publication bias were assessed. Nine case{\textendash}control studies involving 841 periodontitis cases (644 chronic periodontitis and 197 aggressive periodontitis cases) and 748 controls were included. We found statistically significant association of IL-10 -819 (-824) C\&gt;T and IL-10 -592 (-597) C\&gt;A polymorphisms in Caucasians. The IL-10 -819 (-824) T and -592 (-597) A alleles may confer a relative increase in the risk for chronic periodontitis in Caucasians. Future studies may be important to reinforce these findings.</span></p>},
	keywords = {Interleukin-10, Meta-analysis, Periodontitis, Polymorphism},
	issn = {1573-4978},
	doi = {10.1007/s11033-012-1738-1},
	url = {http://link.springer.com/article/10.1007\%2Fs11033-012-1738-1},
	author = {Albuquerque, C. M. and Cortinha, A. J. and Morinha, F. J. and Leit{\~a}o, J. C. and Viegas, C. A. A. and Bastos, E. M.}
}
