@article {17181, title = {Evaluation of the antioxidant activity of new compounds by cyclic voltammetry}, journal = {59th Annual Meeting of the International Society of Electrochemistry}, year = {2012}, month = {2012-01-04 00:00:00}, abstract = {

Reactive oxygen species (ROS), radicals and non-radicals, play an important role in the initiation and evolution of numerous diseases. The use of compounds capable of preventing biological oxidative damage is expected to be useful for the treatment of these diseases. Compounds that are able to prevent oxidative damage are usually denominated antioxidants.

An antioxidant is defined as any substance that, when present at low concentrations compared with those of an oxidizable substrate, significantly delays or prevents oxidation of that substrate.

There has been a growing interest in the synthesis and characterization of novel antioxidants in order to meet the requirements of the pharmaceutical industries.

Several analytical methods have been used to evaluate the activity of antioxidant compounds, such as: the oxygen radical absorbance capacity, the trolox equivalent antioxidant capacity and the diphenyl-1-picrylhydrazylradical (DPPH) assay. Other approaches using electrochemical measurements have also been employed.

The use of electrochemical methods is based on the assumption that the ease of radical formation correlates with the ease of oxidation of the compound in vivo. Several studies suggest that compounds selected on the basis of electrochemical behaviour are likely to be highly active in cell cultures. In this work cyclic voltammetry was used to measure the ease of oxidation of two families of new compounds and the anodic peak potentials were used as a measure of their antioxidant activity.

}, keywords = {Antioxidant activity, cyclic voltammetry}, author = {Amorim, S. and Bettencourt, A. P. and Carvalho, M. A. and Correia, C. C. and Proen{\c c}a, M. F. and Soares, A. M.} }