@article {15730, title = {The Influence of Patterned Nanofiber Meshes on Human Mesenchymal Stem Cells Osteogenesis}, journal = {Macromolecular Bioscience}, volume = {11}, year = {2011}, month = {2011-07-25 00:00:00}, pages = {978{\textendash}987}, abstract = {

A specially designed electroconductive collector enables the electrospinning of P-NFM com- posed of areas of parallel/uniaxially aligned fibers and areas of random/orthogonal nanofiber distribution. The biological relevance of P-NFM is demonstrated using hBMSCs as an auto- logous cell source. The structures induce cell orientation along the uniaxially aligned fibers, mainly during earlier culturing periods under basal and osteogenic differentiation conditions. The microtopography of the P-NFM also controls the depo- sition of mineralized extracellu- lar matrix along the pre-defined fiber direction. Genotypic characterization confirms the successful differentiation into the osteogenic lineage.

}, keywords = {Electrospinning, osteogenic differentiation}, author = {Martins, A. and Alves da Silva, ML and Faria, S. and Marques, A. P. and Reis, R. L. and Neves, N. M.} }