@article {15515, title = {In situ study of partially crystallized Bioglass and hydroxylapatite in vitro bioactivity using atomic force microscopy}, journal = {Journal of Biomedical Materials Research}, volume = {62}, year = {2002}, month = {2002-06-20 00:00:00}, pages = {82-88}, publisher = {Wiley Periodicals, Inc. J}, abstract = {

The present work investigates,\ in situ,\ the\ in vitro\ bioactivity of partially crystallized 45S5 Bioglass{\textregistered} (BG) as a function of immersion time in a simulated body fluid (SBF) using atomic force microscopy (AFM). The results obtained for the crystallized BG{\textregistered} were compared to those of hydroxyapatite c- and a-faces. The calcium phosphate layer grows on the crystallized 45S5 B{\textregistered} by multiple two-dimensional nucleation and fusion of these two-dimensional islands, which is essentially the same mode as for the hydroxyapatite c-face. The surface of the crystallized 45S5 BG{\textregistered} was almost fully covered with a dense and compact calcium phosphate layer after 24 h. The calcium phosphate formation on the crystallized BG{\textregistered} arises from a low surface energy of the surface layer and/or an effect of the layer to lower the resistance when the growth units of calcium phosphate incorporate into the growing island. These results indicate that the crystallized 45S5 BG{\textregistered} is suitable to be used as a filler for polymeric matrix bioactive composites, as it maintains a high bioactivity associated with a stiffer behavior (as compared to standard BG{\textregistered}).

}, keywords = {atomic force microscopy, bioactivity, Bioglass{\textregistered}, in situ, in vitro}, doi = {DOI: 10.1002/jbm.10289}, url = {http://onlinelibrary.wiley.com/doi/10.1002/jbm.v62:1/issuetoc}, author = {Leonor, I. B. and Ito, A. and Onuma, K. and Kanzaki, N. and Zhong, Z. P. and Greenspan, D. and Reis, R. L.} }