@inproceedings {15393, title = {Micro-nano composite mesh scaffold in mouse MPC osteogenic differentiation}, journal = {TISSUE ENGINEERING }, volume = {13}, year = {2010}, month = {2010-03-17 00:00:00}, pages = {1727}, abstract = {

In the biomaterials field, nanofibrous structures and composites are promising materials to produce scaffolds mimicking the architec- ture of the extracellular matrix (ECM). Indeed, the ECM of con- nective tissues is a biological example of a micro-nanofibrous structure. The main objective of this work is to evaluate a novel scaffold produced with microfibres obtained by melt extrusion of a blend of chitosan and a synthetic biodegradable polymer, poly (butylene succinate) (50:50 wt). This blend was also compounded with electrospun chitosan nanofiber meshes (0.05\% wt) to obtain a nano-reinforced composite.

Tensile mechanical testing of the reinforced microfibres showed that the modulus is increased up to 70\% (295.7 }, keywords = {micro-nano scaffolds, osteogenic differentiation}, author = {Martins, A. and Pinho, E. D. and Malafaya, P. B. and Marques, A. P. and Reis, R. L. and Neves, N. M.} }